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ea0020p623 | Reproduction | ECE2009

Effects of thyroid hormones on ovary granulosa cells: regulation of proliferation, survival and function

Misiti Silvia , Falzacappa Cecilia Verga , Mangialardo Claudia , Bucci Barbara , Raffa Salvatore , Silvestrini Giuliana , Stigliano Antonio , Toscano Vincenzo

It is clinically evident that women suffering from thyroid disorders are associated with frequent occurrence of menstrual disturbances and impaired fertility, and these abnormalities are improved by restoring the euthyroid state. The exact mechanism for such reproductive aberrations is not well known; however, it is conceivable that thyroid hormones might have a direct role in ovarian physiology via receptors in granulosa cells. We evaluated the effect of thyroid hormones (T<s...